The Hidden Chain Reaction: How Other Chronic Conditions Are Fueling the Rise in Kidney Disease
New global study reveals kidney disease is rising worldwide—driven by the growing epidemics of diabetes, obesity, and high blood pressure that together form a dangerous cycle of chronic illness.
A groundbreaking new Lancet study, part of the Global Burden of Disease 2023 analysis, has revealed that chronic kidney disease (CKD) is growing faster than almost any other non-communicable disease — and the main reason is its deep connection to other chronic conditions.
In 2023, 788 million adults worldwide were estimated to live with CKD — double the number in 1990. But this rise isn’t happening in isolation. The kidneys are becoming a victim of the global epidemics of diabetes, hypertension, and obesity.
The Web of Chronic Diseases
The study found that:
High blood sugar, high blood pressure, and obesity are the top three risk factors driving kidney disease worldwide.
11.5% of all cardiovascular deaths are linked to impaired kidney function.
People with diabetes or hypertension are far more likely to experience CKD — and vice versa.
This means that kidney disease is both a consequence and a cause of other chronic illnesses. Once kidney function declines, it puts additional stress on the heart, metabolism, and blood vessels, creating a dangerous feedback loop that can shorten life expectancy if not addressed early.
CKD: The Silent Amplifier
Unlike diabetes or heart disease, CKD often develops without noticeable symptoms until it’s advanced. Yet, even mild kidney dysfunction can worsen blood pressure, heart health, and insulin resistance — turning it into what researchers call a “silent amplifier” of chronic disease.
This interconnectedness is why experts are urging a shift toward integrated care, where the kidneys are not treated as an isolated organ but as part of a system deeply connected to metabolic and cardiovascular health.
A Growing Global Impact
CKD is now the 9th leading cause of death globally, responsible for 1.48 million deaths in 2023.
Most people with CKD (about 14%) have early-stage disease (stages 1–3), where lifestyle changes and early treatment can make the biggest difference.
What This Means for People Living with CKD
If you’re living with CKD, it’s crucial to understand that your kidneys, heart, and metabolism are all connected. Managing one condition can protect the others. Here’s what this means in practice:
Monitor your blood pressure and blood sugar regularly — even small improvements matter.
Focus on food as medicine: reduce sodium, limit added sugars, and emphasize whole foods rich in fiber and potassium balance.
Stay active to improve insulin sensitivity and cardiovascular health.
A Call to Reimagine Kidney Care
This study reinforces a key message: kidney disease is not just a kidney problem. It’s a reflection of how our modern lifestyle and chronic conditions interact. By tackling the shared roots — like metabolic health, diet, and blood pressure — we can turn the tide on CKD and its deadly companions.
At Living with CKD, we believe the future of kidney care lies in connection — connecting patients, healthcare systems, and lifestyle science to build a healthier, longer life for everyone affected.
Source:
GBD 2023 Chronic Kidney Disease Collaborators. “Global, regional, and national burden of chronic kidney disease in adults, 1990–2023.” The Lancet, published Nov 7, 2025.
Read the full study here.
With care,
Ewerton Lopes - Living with CKD since 2016
CEO of MetaSano and MetaSano IQ
Integrative Nutrition Specialist
Kidney Health Coach
Gerontologist
Author of the book My Dog, My Healer: My path to overcoming chronic kidney disease
I changed my e-fgr from 59 to 81 by Changi g my diet. It took 8 months. I’m still following diet by biochemist. Have the blood and urine e tests to prove it.